Head on down to your local comic store and flip through the bin of old comics. When you reach the Spider-Man section you will find yourself staring at various covers that feature many villains. None appear more often than the Sinister Six. Over the years, they have put Spider-Man through the ringer and then some. However, unless you are a die-hard fan of the webslinger you may not know very much about who this group is and how they came to be. This is your chance to change all of that and dive head first into the history of Spider-Man and his most notorious villains.

There were six members of the founding team which debuted in the Amazing Spider-Man Annual #1 in 1964. Let's take a look at all of them and their history with Spider-Man.

Doctor Otto Octavius (Doctor Octopus)

He originally appeared in The Amazing Spider-Man #3, a creation of the legendary duo Stan Lee and Steve Ditko. Octavius was described as the man Peter Parker would have become had he not been taught right from wrong by his Aunt and Uncle. Octavius came from a broken and abusive home. He went on to become a nuclear physicist, inventor and lecturer. The mechanical arms he used in battle against Spider-Man were of his own design, and allowed him to possess more physical strength courtesy of the brain-computer interface. After a radiation leak, the apparatus became infused with his body and he turned to a life of criminal activity. He was infamous for beating Spider-Man in their first battle. Octavius had been portrayed in live action by Alfred Molina in Spider-Man 2 who will reprise his role in No Way Home.

Maxwell Dillon (Electro)

Another product of Lee and Ditko, he debuted in The Amazing Spider-Man #9. Max Dillion worked as a lineman and a freak accident with lightning caused him to become a living electric capacitor. He began stealing electrical equipment from Stark Industries to further his powers. During his first fight with Spider-Man, Electro nearly sent enough voltage through Peter to kill him. Spider-Man learned quickly and subsequently defeated him with the use of a fire hose and rubber gloves to short-circuit his powers. Electro had been portrayed in live action by Jamie Foxx in The Amazing Spider-Man 2 who will also reprise his role in No Way Home.

Quentin Beck (Mysterio)

Mysterio made his first appearance in The Amazing Spider-Man #13. He was a Hollywood special effects artist who wanted to become an actor. After a failed attempt to do so, Beck determined that his skill set of illusion and tricks could be better served to aid in criminal activity. Beck created a gas that disrupted Peter's spider senses, and an abrasive that made his webs ineffective. He also framed Spider-Man for robbing the Midtown Museum. Spider-Man later got a confession out of Beck on tape and turned him into the authorities. Beck appeared in live action in Spider-Man: Far From Home, played by Jake Gyllenhaal. In the movie, the character had a slightly different back story as a disgruntled former Stark employee who created a series of disaster illusions so that he could play the part of a hero. He was later stopped by Spider-Man.

Flint Marko (The Sandman)

At the age of three, Marko was abandoned by his father. Originally named William Baker, he chose to change the name after he rigged a football game and later punched his teacher in the face. He eventually landed himself in prison with his own father, but never told him his true identity. After his father was released from prison Marko broke out and headed to a nuclear testing site on a beach near Savannah, Georgia. The sand on the beach, which was exposed to radiation, bonded with Marko’s body, changing his molecular structure to sand. At this point he adopted the villainous moniker “The Sandman.” His first appearance was in The Amazing Spider-Man #4 where his first fight with Spider-Man ended with him being sucked into a vacuum cleaner (which Spider-Man then handed over to the police). Sandman was portrayed by Thomas Haden Church in Spider-Man 3. He will also reprise the role in Spider-Man: No Way Home.

Adrian Toomes (Vulture)

First appearing in The Amazing Spider-Man #2, Toomes was an electrical engineer who went into business. His partner handled the finances while Toomes was the brains behind the operation. When he discovered that his partner was embezzling the funds, he became frustrated that he had no legal recourse. Toomes then discovered that a harness he had been working on gave him super strength. He then used the harness to create his criminal identity known as “Vulture” as it gave him the ability to fly. Michael Keaton portrayed Adrian Toomes in Spider-Man: Homecoming.

Sergei Kravinoff (Kraven The Hunter)

Kraven made his debut in The Amazing Spider-Man #15. After his family was forced to relocate to the U.S. after the February Revolution of 1917, Sergei became a big game hunter. He did not use guns or bows, and desperately wanted to be known as the only hunter to take his prey down with his bare hands. He saw Spider-Man as the biggest takedown he could have. He did take a mystical serum to enhance his natural physical strength as well as slow down the aging process. Kraven was the only member of the Sinister Six that had not made a live action appearance. However, within the Sony Spider-Man universe there have been multiple teases that he may be getting a solo movie akin to Venom and Morbius. If that does in fact happen it would complete the Sinister Six in live action.

By creating these characters, Stan Lee and Steve Ditko have changed comics forever. The Sinister Six will continue to have an impact on the medium for decades to come. After all, they are some of the most recognized faces in all of the villainy that occurs throughout the Multiverse.